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Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Diabetic retinopathy DR is the most common microvascular complication of diabetes and is strongly linked with systemic vascular comorbidities.
This was a prospective cohort study of adult participants who presented to a tertiary Australian hospital for evaluation of acute coronary syndrome by coronary angiography. Coronary artery disease was graded from coronary angiograms using the Gensini score. CVD mortality follow-up was assessed 9 years after baseline examination using linkage with the Australian National Death Index.
At baseline, There were After controlling for age, sex, BMI, diabetes, total cholesterol, smoking status, hypertension, previous myocardial infarction and stroke, any DR was associated with 1. Mild non-proliferative DR 1. Further adjustment for coronary artery disease using Gensini scores and excluding patients without diabetes had minimal impact on the association. The increased risk of CVD mortality was significant in both men 2. This likely reflects additional contribution of microvascular disease to CVD mortality.
Individuals with DR may benefit from a comprehensive cardiovascular risk assessment, lifestyle changes, more intensive cardiovascular management and follow-up to minimise risk of death from CVD events. Diabetes mellitus has become a major public health challenge and is a significant cause of morbidity and mortality.
According to the International Diabetes Federation, the number of individuals living with diabetes globally in is estimated to be million 1. This number is projected to increase to million by and million by 1. In , diabetes was attributed to four million deaths worldwide and the global health expenditure on diabetes was around USD billion 1. Diabetes is associated with both macrovascular and microvascular complications that affect health, quality of life and lead to premature death. Macrovascular complications include accelerated cardiovascular disease, cerebrovascular events and peripheral vascular disease 2.