Official websites use. Share sensitive information only on official, secure websites. Correspondence: gabriela. Petitgrain essential oil PGEO is derived from the water distillation process on mandarin Citrus reticulata leaves. The major peaks were for methyl-N-methyl anthranilate Anxiety-like behavior and memory of the zebrafish were assessed by a novel tank diving test NTT , Y-maze test, and novel object recognition test NOR.
Cognitive decline is a prevalent problem in the elderly population and is a prominent factor in mortality rates. World Health Organization projections suggest that more than 55 million people globally experience severe cognitive impairment, also known as dementia.
Dementia significantly impairs the well-being of patients and their families, placing significant strain on health systems, communities, and the global financial landscape. With aging demographics on a global scale and the extended lifespan of people affected by dementia, it is anticipated that the repercussions of this condition will increase.
AD is a complex neurodegenerative condition, characterized by the presence of distinctive pathological changes at the brain level. Important consequences of NFTs are determined by the mislocalization of the tau protein inside nerve cells. The tau protein is normally present in neuronal axons, where it helps maintain their structure and function.
However, when hyperphosphorylated, the tau protein mislocalizes to other parts of the nerve cell, including dendritic spines, thereby affecting the ability of neurons to communicate effectively with each other [ 3 ].
