Clinics is a gold open access electronic international journal that publishes peer-reviewed research in continuous flow of interest to clinicians and researchers in medical and biomedical sciences based on its originality, importance, conclusions and interest to readers. The journal is committed to the principles of ethics, respect for the individual, humanization, honesty, pioneering spirit and excellence.
The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. SRJ is a prestige metric based on the idea that not all citations are the same. SJR uses a similar algorithm as the Google page rank; it provides a quantitative and qualitative measure of the journal's impact.
SNIP measures contextual citation impact by wighting citations based on the total number of citations in a subject field. This study aimed to explore the relationship between plasma interleukin 6 IL-6 levels, adverse cardiovascular events, and the severity of acute coronary syndrome ACS. The literature was screened, its quality was evaluated, and relevant data were extracted for performing meta-analysis using RevMan software version 5.
A total of studies were included in the initial survey. After several rounds of screening and analysis, six studies met the inclusion criteria and underwent meta-analysis using a fixed-effect model. Patients were divided into non-severe and severe groups based on the concentration of high-sensitivity C-reactive protein. In summary, patients with ACS and high IL-6 levels tended to be in a critical condition, with a higher risk of adverse cardiovascular events and worse prognosis.
The interaction of these cytokines is involved in the process of atherosclerotic plaque destabilization, which results in ACS. Since its detection is rapid and easy to perform, IL-6 has gradually become a commonly used indicator in clinical practice 2 and is strongly associated with the severity of ACS.
