The authors note that transferrin saturation levels may be a modifiable risk factor of chronic kidney disease CKD progression and all-cause mortality. Iron deficiency appears frequently in patients who have chronic kidney disease CKD , including those without anemia. Authors of a study published in Nutrition Journal investigated the association between iron deficiency and the risks of CKD progression and all-cause mortality.
This multicenter, retrospective, nationwide cohort study included adult patients with non-anemia NDD-CKD from 24 hospitals across China from January 1, , to December 31, The study investigated the associations between serum ferritin or transferrin saturation TSAT levels and the risks of CKD progression and all-cause mortality. Patients who had either ferritin or TSAT, or both, were included in the study. Additionally, baseline was defined as the first hospitalization with available ferritin or TSAT.
The investigators used 2 datasets for analytical purposes. The dataset for the analysis of kidney disease progression did not include patients without repeated eGFR measurement after discharge, and the dataset for the analysis of all-cause mortality did not include patients without identifiable information from the national electronic cause-of-death reporting system of the China Center for Disease Control and Prevention.
Follow-up was discontinued when patients either reached the study outcome or when their last available serum creatinine measurement was recorded. The secondary outcome was all-cause mortality, which was determined using records from the national electronic cause-of-death reporting system. Follow-up commenced at discharge and continued until either death or the last date recorded in the electronic medical record. Among the enrolled 18, patients with NDD-CKD, patients were included in the kidney outcome analysis, and 18, patients were included in the all-cause mortality analysis.
Of the patients with the measurement, approximately Pharmacy Focus: World Psychedelics Day. All News. FDA Updates. Press Releases. All Videos. Digital Detail. Independent Corner. Medical World News.
