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Search Access content directly Footer. Sign in. Search Loading Search using SolR syntax. Search using SolR syntax Run the search. Institute for Translational Research in Inflammation - U Institute for Research and Innovation in Biomedicine. Abstract en. Background: Anal ulcerations are frequently observed in Crohn's disease CD. However, their natural history remains poorly known, especially in pediatric-onset CD.
Methods: All patients with a diagnosis of CD before the age of 17 years between and within the population-based registry EPIMAD were followed retrospectively until At diagnosis and during follow-up, the clinical and therapeutic features of perianal disease were recorded. An adjusted time-dependent Cox model was used to evaluate the risk of evolution of anal ulcerations towards suppurative lesions.
Results: Among the 1, included patients females, Cumulative incidence of anal ulceration at 5 and 10 years from diagnosis was In multivariable analysis, the presence of extra-intestinal manifestations Hazard Ratio HR 1. No file. Dates and versions hal , version 1 The American Journal of Gastroenterology , , 9 , pp.
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