Official websites use. Share sensitive information only on official, secure websites. For the current review a literature search was carried out using Pubmed, EmBase, and Cochrane databases. All cases of prostate angioscaroma reported to date and observational studies evaluating the radiation associated cancer occurrence were reviewed. Despite the rarity, prostate angiosarcomas display remarkable clinical and pathological heterogeneity, and a treatment challenge. We found the association of prostate angiosarcoma with radiation therapy to be weak based upon the results from observational studies and case reports.
Although radiation exposure has been suggested etiology of prostate angiosarcomas, assumption of such association is not supported by the current literature. Keywords: prostate angiosarcoma, radiation therapy, adjuvant chemotherapy, multidisciplinary management. Sarcomas are malignant mesenchymal tumours. They frequently involve the skin, breast and soft tissue [ 1 ]. These very rare malignant neoplasms only 10 identified in the current world literature originate from the blood vessel endothelium and are distinguished by atypical, solid or multilayered endothelial proliferation [ 1 ].
In the present paper, we provide a review of prostate angiosarcomas, highlighting their epidemiology, aetiology, clinical presentation, histological features, prognostic factors and current treatment options. Prostate angiosarcoma is an almost non-existent entity and the disease progression and prognosis of these tumours is poorly understood. A peak incidence has been noted between the ages of 40—50 and 70—80 years mean age: 40 years in the literature.
One case even involved a 2-year-old child. Smith et al. Chan et al. Chandan and Wolsh [ 9 ] reported the seventh case of angiosarcoma of the prostate in a patient who received radiation therapy for prostate adenocarcinoma 10 years earlier.
Lee et al. Guo et al. Khaliq et al. Previous radiation exposure is a well-known risk factor for angiosarcomas. The direct oncogenic effects of ionizing radiation and prolonged cellular stimulation during repair of tissue damage resulting from radiation-induced ischaemic change are thought to play a role in the development of angiosarcoma [ 13 ].
