Lyophilised powder for solution for injection. Toxic reactions due to 'Cosmegen' are frequent and may be severe see 4. However, the severity of toxicity varies markedly and is only partly dependent on the dosage used.
Intravenous use. The dosage of 'Cosmegen' will vary with the tolerance of the patient, the size and location of the neoplasm, and the use of other forms of therapy.
It may be necessary to reduce the usual dosage suggested below when additional chemotherapy or radiation therapy is used concurrently or has been employed previously. The dosage of 'Cosmegen' is calculated in micrograms.
The dose intensity per-two-week cycle for adults or children should not exceed 15 micrograms per kg per day or micrograms per square meter of body surface daily, intravenously, for five days. Calculation of the dosage for obese or oedematous patients should be on the basis of surface area in an effort to relate dosage to lean body mass.
As there is a greater frequency of toxic effects of 'Cosmegen' in infants, 'Cosmegen' should only be given to infants under the age of 12 months, when the benefit outweighs the risk. A wide variety of single agent and combination chemotherapy regimens with 'Cosmegen' may be employed. Because chemotherapeutic regimens are constantly changing, dosing and administration should be performed under the direct supervision of physicians familiar with current oncologic practices and new advances in therapy.
