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If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. In a preclinical model of neuroblastoma, Dearling et al.
In the pre-clinical framework of Dearling et al. Assuming irreversible trapping, when PET imaging is acquired at peak time of decay-uncorrected trapped-tracer-activity concentration, it has been shown that [ 3 ]:. Incorporating Eq. Mean blood-clearance data provided by Dearling et al. Peak time could thus be graphically determined, and, when solving Eq. The trapped-tracer time-activity curve TAC; in arbitrary unit was drawn by setting an arbitrary K i-D value of 0. In comparison with the trapped-tracer TAC, the tumor TAC additionally involves free tracer in blood and interstitial volume, of which fraction F D was arbitrarily set to 0.
Figure 1 also shows the corresponding SUR-versus-time curve. Peak time of decay-uncorrected trapped-tracer activity concentration is indicated. In this framework, Eq. The assumptions made for deriving Eq. The SUR increases with time Fig. However, Hofheinz et al. However, a convolutional neural network has been recently investigated in humans that can provide robust automatic image-based mean values of [ 18 F]-FDG SUV Blood over the aorta.
Equation 6 might be further simplified by using a mean value for F, obtained from experiments that remain to be performed. The scope of Eq. We suggest that it might be of interest for future clinical theranostic practice.
