Official websites use. Share sensitive information only on official, secure websites. A palliative approach to intensive care unit ICU patients with acute respiratory failure and a do-not-intubate order corresponds to a poorly evaluated target for non-invasive oxygenation treatments. We aim to conduct a prospective multicentre observational study to analyse clinical practices and their impact on outcomes of palliative high-flow nasal oxygen therapy HFOT and non-invasive ventilation NIV in ICU patients with do-not-intubate orders.
This is an investigator-initiated, multicentre prospective observational cohort study comparing the three following strategies of oxygenation: HFOT alone, NIV alternating with HFOT and NIV alternating with standard oxygen in patients admitted in the ICU for acute respiratory failure with a do-not-intubate order.
The sample size was estimated at a minimum of patients divided into three groups according to the oxygenation strategy applied. The analysis takes into account confounding factors by modelling a propensity score. The study has been approved by the ethics committee and patients will be included after informed consent. The results will be submitted for publication in peer-reviewed journals.
This trial will be the largest prospective study specifically targeted on palliative use of non-invasive oxygenation strategies in patients admitted to intensive care unit for acute respiratory failure with do-not-intubate order.
The study will also include patients who have been intubated and then developed post-extubation respiratory failure with a do-not-reintubate order. There are currently very limited data concerning this patient subgroup.
