Alicia Benson-Rumiz : Connectez-vous pour contacter le contributeur. Documentation Se connecter. Recherche Loading Recherche experte SolR. Recherche experte SolR Lancer la recherche. Introduction and aims : Periodontitis, the main cause of tooth loss in adults, is a public health concern; its incidence increases with age, and its prevalence increases with increasing life expectancy of the population. Innovative therapies such as cell therapy represent promising future solutions for guided tissue regeneration.
However, these therapies may be associated with fears and mistrust from the general public. The aim of this study was to estimate the acceptability of an advanced therapy medicinal product combining allogeneic mesenchymal stromal cells from adipose tissue with a natural fibrin hydrogel in the treatment of periodontitis.
Methods : The methodology was based on a qualitative study conducted through semi-structured interviews with patients followed for periodontitis in the Oral Medicine Department of the Toulouse University Hospital, Toulouse, France.
Qualitative studies are essential methodologies to understand the patterns of health behaviours, describe illness experiences, and design health interventions in a humanistic and person-centred way of discovering. Results : Eleven interviews with 4 men and 7 women were required to reach thematic saturation. Analysis allowed 4 main themes to emerge: 1 perception of new treatments, science, and caregivers; 2 conditions that the treatment must meet; 3 patient perception of the disease; and 4 factors related to the content of the treatment.
Conclusions : Patients find cell therapy for periodontitis to be acceptable. Periodontitis is a prototypical model of chronic inflammatory pathology and is multitissular, with hard- and soft-tissue lesions.
