Metrics details. Monkeypox is a zoonotic viral infection first reported in May This study systematically reviews the monkeypox cases presented with any cardiac complications. A systematic literature search was done to locate papers that discuss any cardiac complications associated with monkeypox; then, data were analyzed qualitatively.
Nine articles, including the 13 cases that reported cardiac complications of the disease, were included in the review. Five cases previously had sex with men, and two cases had unprotected intercourse, which reveals the importance of the sexual route in disease transmission. All cases have a wide spectrum of cardiac complications, such as acute myocarditis, pericarditis, pericardial effusion, and myopericarditis. This study clarifies the potential for cardiac complications in monkeypox cases and provides avenues for future research to determine the underlying mechanism.
Also, we found that the cases with pericarditis were treated with colchicine, and those with myocarditis were treated with supportive care or cardioprotective treatment Bisoprolol and Ramipril. Furthermore, Tecovirimat is used as an antiviral drug for 14 days. Peer Review reports. Monkeypox Mpox is a viral zoonotic disease caused by the Mpox virus, a member of the Orthopoxviral genus from the Poxviridae family of viruses [ 1 ].
The first human Mpox case was detected in [ 2 ]. Mpox was mainly endemic to central and western Africa, with a few sporadic cases outside Africa. Traveling to the endemic regions and importing animals such as Squirrels and rodents from Ghana in led to the Mpox outbreak in the United States [ 3 ]. In from a traveler who returned from Nigeria then, the cases started to increase, which prompted the WHO to declare the Mpox disease as a public health emergency of international concern to raise awareness about it and promote the countries' preparedness [ 4 ].
According to the Center for Disease Control and Prevention CDC , the total number of Mpox cases is 87, in both the endemic and non-endemic sites of the disease [ 5 ]. The disease manifestation starts with a prodromal phase of fever, headache, myalgia, and lymphadenopathy, followed by the eruption of multiple swollen and umbilicated cutaneous lesions on the patient's face, hands, and genitalia. Anal pain and the other features last five days, a common period of Orthopoxviruses , followed by a rash.
