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How testosterone protects against inflammation | ScienceDaily

Knowledge of the etiology and pathogenesis of most prostate malfunctions and pathologies is very limited. Despite advances in medicine, the differential diagnosis of benign hypertrophic and carcinogenic prostate has steadily increased in complexity and controversy. It has been suggested that the prostate bismuth Bi level may help solve these problems related to prostate disorders, especially as an indicator of prostate cancer risk, as an elevated Bi level in the prostate may be a sign of prostate cancer in the future.

These suggestions promoted more detailed studies of the Bi level in the prostate of healthy men. In present review we analyze data published concerning Bi prostatic levels in healthy persons. In this way the disparate nature of published Bi content of normal prostates was evaluated. Of the articles examined, 15 were selected for objective analysis of data from healthy subjects. The contents of prostatic Bi on a wet mass basis spanned the interval from 0.

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Keywords: Bismuth, Human prostate gland, Normal prostatic tissue, Biomarkers. Amongst the many pathological prostatic conditions, prostatic carcinoma PCa , chronic prostatitis and benign prostatic hyperplasia BPH are very frequently encountered, especially in the elderly []. Their causes and pathogenesis are poorly understood.

Moreover, despite biomedical advances, the differential diagnosis of prostate diseases has become progressively more complex and controversial. In our previous studies the involvement of trace elements TEs in the function of the prostate gland was indicated. It was also found that content of TEs in prostatic tissue, including bismuth Bi , can play a significant role in etiology of PCa []. The first data of Bi content in human prostatic tissue 0.

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Zakutinsky [29] and Tipton and Cook [30] indicated that the content of Bi in the human prostate equals or below than 0. This finding allowed conclude that the prostate can accumulate Bi, because the level of metal in glands was almost four orders of magnitude higher the blood level 0.

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