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Official websites use. Share sensitive information only on official, secure websites. Address correspondence to:, Wendy J. Prostate epithelial differentiation was studied using histology, sphere formation assay, and prostate regeneration induced by cycles of repeated androgen withdrawal and replacement.
Embryonic deletion of Abcg2 resulted in a decreased number of luminal cells in the prostate and increased sphere formation efficiency, indicating an imbalance in the prostate epithelial differentiation pattern.
Decreased luminal cell number in the Abcg2 null prostate implies reduced differentiation. Pharmacological inhibition of MDR-ABC efflux enhanced prostate epithelial differentiation in sphere culture and during prostate regeneration.
Our study demonstrates for the first time that MDR-ABC efflux transporter inhibition results in enhanced prostate epithelial cell differentiation. P renatal and postnatal murine prostate development has been extensively studied to understand the prostate epithelial differentiation hierarchy and signaling pathways involved in the developing prostate [ 1 ].
One theory of prostate epithelial differentiation is that basal and luminal cells differentiate from adult stem cells [ 2 ]. Classic androgen deprivation and regeneration studies demonstrated that adult stem cells are present in the basal layer of the prostate gland [ 3β5 ].