Official websites use. Share sensitive information only on official, secure websites. Corresponding author. Phone: 33 1 47 60 60 Fax: 33 1 47 60 60 E-mail: marie-laure. Joly-Guillou, M. Wolff, J. Pocidalo, F. Walker, and C. Carbon, Antimicrob. Agents Chemother. Two aspects of the therapeutic response were studied: the kinetics of the bactericidal effect treatment was initiated 3 h after intratracheal inoculation, and bacterial counts were determined over a h period and survival treatment was initiated 8 h after inoculation, and the cumulative mortality rate was assessed on day 5.
Against SAN, four regimens, i. The best survival rate i. Against RCH, only regimens containing rifampin and the combination of imipenem-sulbactam had a true bactericidal effect. Acinetobacter baumannii is recognized as an increasingly resistant nosocomial pathogen, responsible for pneumonia especially in mechanically ventilated patients 7.
Recent isolates of A. The majority of clinical isolates of A. In addition, strains resistant to virtually all antibiotics, including imipenem, were recently responsible for outbreaks in intensive care unit patients 9. We previously demonstrated the enhanced in vitro killing of A.
When we assessed the in vitro activities of rifampin against 30 strains of A. We recently described a new mouse model of A. The antimicrobial agents used in this study were obtained from laboratory standard powders and were used immediately after being diluted. Two different strains were used. SAN is a cephalosporinase-overproducing strain resistant to aminoglycosides and fluoroquinolones but susceptible to imipenem, ticarcillin, and sulbactam. It was isolated from the blood culture of a patient with nosocomial pneumonia.
RCH is a multiresistant strain with low susceptibility to imipenem and susceptibility only to rifampin. It was isolated from the peritoneal fluid of a patient with postoperative peritonitis.
