Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Dysregulation of glucose metabolism and inflammation are key factors in the development of atherosclerosis.
The glucose-to-lymphocyte ratio GLR is a comprehensive marker for assessing glucose metabolism and inflammation. Weighted Cox proportional hazard models were used to assess the independent association between GLR and mortality risk.
Restricted cubic spline RCS curves were used to display the relationship between GLR and all-cause mortality visually, and two-segment Cox proportional hazards models were constructed on either side of the inflection points. Kaplan-Meier survival curves were further used to assess the relationship between GLR and mortality, and further subgroup analyses were performed. Receiver operating characteristic curve ROC analysis was conducted to assess the predictive ability of GLR for survival.
During a median follow-up of 6. In addition, an interaction was detected between GLR and age in relation to all-cause mortality. Moreover, the predictive performance of GLR on all-cause and CVD mortality seemed superior to that of glucose or lymphocytes. Notably, the relationship between GLR and all-cause mortality exhibited a J-shaped nonlinear pattern, with an inflection point at 3. Atherosclerosis refers to the formation of fibrofatty lesions in the arterial walls.
Cardiovascular disease CVD caused by atherosclerosis are collectively termed atherosclerotic cardiovascular disease ASCVD , which include ischemic stroke, ischemic heart disease, and peripheral arterial atherosclerotic vascular disease 1. Recent research indicates that over the past thirty years, the prevalence and related deaths from CVD worldwide have significantly increased, from million to million people 2.
