Official websites use. Share sensitive information only on official, secure websites. Peluso 1 , N. Iyer 1 , S. Kumar 1 , S. Munter 1 , L.
Torres 1 , R. Deeks 1 , W. Trypsteen 2 , T. Henrich 1. Many individuals had no detectable intact proviruses. Results: Of the 74 controllers, 41 Detectable levels of intact provirus ranged from Conclusions: Elite controllers have low levels of intact provirus, but the level of transcriptional activity is directly correlated with the frequency of intact virions. Lemoine 2 , M.
Gousset 1 , A. Boufassa 3 , O. Gascuel 2 , O. Lambotte 4 , L. Hocqueloux 5 , A. Rouzioux 6 , V. We characterized HIV blood reservoir to better understand this control.
Bioinformatic tools were developed to identify genetic defects. No difference was observed in the amounts of intact proviruses between groups. A subsequent sample taken four to six years later for three PTCs revealed no evolution of the proviral quasispecies and defects. A deletion in the nef gene was observed in every proviral sequence of two HICs, suggesting a role of these attenuated strains in the viral control in these HICs.
Conclusions: For the first time, we show the presence of intact proviruses and a stable and low viral diversity in PTCs after treatment interruption, reflecting a low residual replication over years. The difference of defective but not intact proviruses amounts between groups suggests a role of these forms in the pathogenesis of HIV infection.
