Background: Large tidal volumes during de novo acute hypoxemic respiratory failure AHRF may promote patient self-inflicted lung injury. Tidal volume assessment under high flow nasal cannula HFNC is not routinely feasible at the bedside. Tidal volume during HFNC was calculated based on tidal impedance variation. CPAP and HFNC were compared in terms of tidal volume, minute ventilation, respiratory comfort, dyspnea, oxygenation, ventilation distribution, end-expiratory lung volume, thoraco-abdominal asynchrony and recruitment.
Tidal volume under CPAP was higher 9. Bland-Altman analysis showed a bias of 2. It decreased signs of respiratory distress in the most severe patients but was associated with lower comfort compared to HFNC. Such low-level CPAP was associated with increased tidal volume, minute ventilation, end-expiratory volume, and oxygenation. Trial registration: ClinicalTrials. Registration date: Keywords: Acute hypoxemic respiratory failure; Continuous positive airway pressure; High flow nasal cannula; Noninvasive ventilation; Respiratory support.
Abstract Background: Large tidal volumes during de novo acute hypoxemic respiratory failure AHRF may promote patient self-inflicted lung injury. Associated data ClinicalTrials.
