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The biological mechanisms by which cleaning products and disinfectantsβan emerging risk factorβaffect respiratory health remain incompletely evaluated. We identified interactions between genetic polymorphisms of a large set of genes involved in the response to oxidative stress and occupational exposures to low molecular weight LMW agents or irritants on adult-onset asthma.
Occupational exposures were evaluated using an asthma job-exposure matrix and job-specific questionnaires for cleaners and healthcare workers. Results were consistent across the three studies and after accounting for smoking. Using a pathway-based selection process, we identified novel genes potentially involved in adult asthma by interaction with occupational exposure. Genes interacting with occupational exposures to low molecular weight agents and irritants on adult-onset asthma in three European studies.
Recent reviews regarding the role of environmental risk factors in adult-onset asthma showed that occupational exposures are important causes of asthma in adults Le Moual et al. Exposure to cleaning agents is an emerging risk factor for adult-onset asthma.
Evidence of adverse effects of cleaning products and disinfectants in asthma mostly comes from studies on occupational risk factors Siracusa et al. Some of the numerous agents contained in cleaning products and disinfectants are chemical sensitizers, but most are hypothesized to act as respiratory irritants Siracusa et al.
