Official websites use. Share sensitive information only on official, secure websites. Cardiac troponin is used as a prognostic biomarker after cardiac surgery.
However, numerous confounding elements, such as inflammation, liver and renal function biomarkers, have been associated with troponin variations. Furthermore, several thresholds regarding the definition of myocardial infarction have been suggested.
We aimed to confirm the accuracy of troponin, analysed as time-dependent variable, to predict mortality independently from other biomarkers; and to assess the incidence and prognosis of a 10 times upper normal value threshold troponin 10N used in the current fourth definition of myocardial infarction. In a prospective cohort of patients who underwent cardiopulmonary bypass cardiac procedures, we assessed the association between serum levels of troponin, creatinine, bilirubin, serum glutamic-oxaloacetic transaminase SGOT , serum glutamic pyruvic transaminase SGPT , C-reactive protein CRP , lactate and in-hospital mortality.
Several models were tested, including time-dependent Cox regression, survival and latent class analyses. Repetitive measurements were accounted for. We included patients. In-hospital mortality was 2. Troponin was independently associated with mortality in all models, after adjusting for other biomarkers.
Similarly, renal function was independently associated with mortality. Conversely, CRP and liver biomarkers were not associated with mortality, once adjusting for other confounders. We confirmed that troponin increase was independently associated with mortality after cardiac surgery.
