Large molecules are used commonly in modern gene therapy and vaccines products, and include virus particles, vesicles, RNA, plasmids, and other forms of DNA. These molecules require dedicated solutions for chromatographic purification. Pre-configured product packs are also available, a combination of columns and a protocol to suit specific needs. Consult Our Experts. Large biomolecules are becoming increasingly popular in the biotherapeutic industry.
Innovative solutions - such as monolithic chromatography - are needed to purify these new modalities. Join us on a journey through the monolith matrix to discover how convective chromatography supports the robust separation of large biomolecules. Join our webinar to learn what makes monoliths ideal for the challenges of purifying large biomolecules. Increased throughput from improved yields and faster run times, benefitting from high capacity and ready-to-use formats.
Choose Your Product. High surface accessibility of binding sites allows capacities beyond resin-based columns for large biomolecules, as well as rapid convection-based mass transfer. With flow-independent performance, low back-pressure, and versatility our monolithic columns facilitate faster purification of your viruses or nucleic acids.
Sartorius experts represent extensive experience in chromatography and purification of biomolecules as well as analytical methods development. Benefit from all the attributes of monolithic chromatography with a range of strong and weak anion and cation exchangers to meet the needs for purification of large biomolecules. Request a Quote. Binds molecules with predominantly positive charge, repels molecules with predominantly negative charge. Binds molecules with predominantly negative charge, repels molecules with predominantly positive charge.
Hydrophobic interaction chromatography HIC is a must for nucleic acid separations. When combined with the advantages of monolithic chromatography, HIC meets this need while also providing an excellent solution for the purification of large biomolecules including adenoassociated viruses AAV.
