Official websites use. Share sensitive information only on official, secure websites. Correspondence: anwalduck csu. Nanoparticles show great promise as a platform for developing vaccines for the prevention of infectious disease.
We have been investigating a method whereby nanocapsules can be formulated from protein, such that the final capsules contain only the cross-linked protein itself.
Such nanocapsules are made using a silica templating system and can be customised in terms of size and porosity. Here we compare the construction and characteristics of nanocapsules from four different proteins: one a model protein ovalbumin and three from infectious disease pathogens, namely the influenza virus, Helicobacter pylori and HIV. Two of the nanocapsules were assessed further. We confirm that nanocapsules constructed from the urease A subunit of H. Further, we show that capsules constructed from the HIV gp protein can be taken up by dendritic cells in tissue culture and can be recognised by antibodies raised against the virus.
These results point to the utility of this method in constructing protein-only nanocapsules from proteins of varying sizes and isoelectric points. Keywords: nanoparticles, vaccines, influenza virus, Helicobacter pylori , HIV. The emergence of SARS-CoV-2 and the resultant COVID pandemic taught us a great deal, with a major lesson being the need to be able to quickly develop vaccines using a variety of different technologies, some of which had not been used in human vaccines previously.
In preparation for the emergence of new pathogens, which almost certainly will happen, it is vital to keep developing a variety of platforms for vaccines.
