Single-photon emission tomography SPET with technetiumm sestamibi MIBI was carried out in 61 adult patients with supratentorial expanding brain lesions. Thirty-one patients had pathologically proven malignant glioma.
Ten patients had pathologically proven low-grade glioma, while another 12 patients had a clinical diagnosis of low-grade glioma. The other eight patients had a variety of lesions including radiation necrosis 3 , abscess 2 , ischaemic stroke 2 and primary brain lymphoma 1. Using computed tomography or magnetic resonance imaging guidance, a MIBI uptake index was computed as the ratio of counts in the lesion to counts in the contralateral homologous region.
In high-grade gliomas, the MIBI index ranged from 1. No significant difference was found between the two low-grade groups 1. No overlap was found between high-grade and low-grade glioma index values. Patients with suspected radiation necrosis, cerebral abscess or ischaemic stroke did not demonstrate high MIBI uptake 0.
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